Cell Division Research
Decoding the Mechanisms ofCell Cycle Control
We are investigating how cells switch between interphase and mitosis. We explore basic cell cycle control mechanisms and potential applications in cancer therapy. As part of this process we are also developing new genetic, and computational tools to study cell cycle control.
Who We Are
We are a group of experimental and computational cell biologists at the Genome Damage and Stability Centre, University of Sussex. We are passionate about understanding how cells divide and maintain genomic integrity. Our mission is to advance fundamental knowledge of cell cycle control while informing the development of targeted cancer therapies.
Contact Us
Genome Damage and Stability Centre
University of Sussex
Brighton BN1 9RQ
United Kingdom
Latest Projects
Our current research focuses on understanding cell cycle control mechanisms and their therapeutic implications
Greatwall Inhibition
translationalDeveloping small molecule inhibitors targeting the Greatwall kinase pathway to enhance cancer cell sensitivity to mitotic drugs. This project aims to identify novel therapeutic strategies for treatment-resistant tumors.
PI: Robert Zach
Exploring the dynamic regulation of mitotic entry
basicInvestigating the molecular crosstalk between Cdk1 and PP2A regulation in late G2 phase. We are exploring how this complex signalling module ensures that mitosis occurs at the right time and proceeds reliably.
PI: Sam Dias, Megan Meredith
OMERO-Screen
toolImplementing an advanced high-content screening platform using OMERO for automated analysis of cellcycle phenotypes. This infrastructure will accelerate our single cell analysis of mitotic entry.
PI: Helfrid Hochegger
Python for Biologists
teachingTeaching computational skills to life scientists through hands-on Python programming courses. We cover data analysis, visualization, and automation to empower biologists with modern computational tools.
PI: Helfrid Hochegger, Jo Renault
Lab News
Stay updated with the latest developments, publications, and team updates from our laboratory
Our paper on Greatwall kinase inhibition and dependency prediction has been published
Our latest research on Greatwall kinase regulation during mitosis has been publiched in Nature Communications. This work reveals new insights into why some cells are more sensitive to Greatwall kinase inhibitors.
View publicationJuly 18, 2025New PhD Student Joining the Lab
We're excited to welcome Sam Jones to our team. Sam will be working on working on the activation mechanism of Greatwall kinase in mitosis.
July 15, 2025